Metabolic remodeling in chronic heart failure
نویسندگان
چکیده
منابع مشابه
Chronic heart failure: a reversible metabolic syndrome?
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In recent years, an interesting shift in our understanding of chronic heart failure (CHF) pathophysiology may be observed. Beyond the traditional concepts of hemodynamic failure and neuroendocrine activation, it is increasingly appreciated that CHF is a much more complex and truly systemic disease including the peripheral organs and whole body regulatory processes as well. Novel concepts such a...
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Heart failure is a progressive syndrome marked by systemic and pulmonary venous congestion, and maladaptive neuroendocrine activation in the setting of structural heart disease. Another facet of this syndrome has recently emerged, involving metabolic dysregulation, which implicates adipose tissue, skeletal muscle and the endocrine systems (insulin, leptin, adiponectin) in interacting with the f...
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heart failure (hf) is one of the main causes of death and disability in the world. the prevalence of hf in developed countries is between 1% and 2% of the adult population and approximately between 6% and 10% in the elderly, giving rise to high costs of care and treatment. indeed, in the united states, the direct and indirect costs exceeded 23 billion dollars in 2002. hf is typically character...
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Although neurohumoral antagonism has successfully reduced heart failure morbidity and mortality, the residual disability and death rate remains unacceptably high. Though abnormalities of myocardial metabolism are associated with heart failure, recent data suggest that heart failure may itself promote metabolic changes such as insulin resistance, in part through neurohumoral activation. A detrim...
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ژورنال
عنوان ژورنال: Journal of Zhejiang University SCIENCE B
سال: 2013
ISSN: 1673-1581,1862-1783
DOI: 10.1631/jzus.b1300137